My present research interest lies in understanding the role of specific nutrients like vitamin in immune system. We would determine how the nutrients affect the adaptive immune system by regulating the development of T helper cells. T helper cells play important role in protecting us from various pathogens by producing cytokines. However, if unregulated the immune responses generated by T helper cells can cause various inflammatory disorders. Based on the cytokines in the microenvironment and produced and the expression of transcription factors, T helper cells have been classified into distinct subsets. Among different vitamins, role of vitamin A and vitamin D have been explored in the differentiation of certain T helper cells. In addition, the function of these vitamins have also been explored in disease models like allergic asthma and experimental autoimmune encephalomyelitis. We would like to define how vitamin A and D regulate the development of various T helper cells including IL-9-producing Th9 cells. Th9 cells play important role in the development of asthma, exacerbate ulcerative colitis; while they aid in the expulsion of helminthic infection and antitumor activity in mouse model of melanoma. Thus, delineating the role of vitamin A and vitamin D in regulating the differentiation of Th9 cells will aid us developing future therapeutics. We would like to build a network of inflammatory diseases whereby IL-9 play key role.
We are also intersted in understanding the role of the Hox family of transcription factors in the differentiation of T helper cells.
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Calcitriol and Retinoic acid antagonize each other to suppress the production of IL-9 by Th9 cells Vyas S. P., Goswami R. By Journal of Nutritional Biochemistry - (2021)
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Systemic innate immune activation in food protein-induced enterocolitis syndrome Goswami R., Blazquez A. , Nowak-wegrzyn A. , Kosoy R. , Rahman A. , Berin M. By Journal of Allergy & Clinical Immunology 1885-1896 (2017)
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Calcitriol attenuates TLR2/IL-33 signaling pathway to repress Th9 cell differentiation and potentially limits the pathophysiology of Rheumatoid Arthritis Vyas S. P., Srivastava R. N., Goswami R. By Molecular and Cellular Biochemistry 476 369-384 (2021)
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Calcitriol Regulates the Differentiation of IL-9-Secreting Th9 Cells by Modulating the Transcription Factor PU.1 Vyas S. P., Hansda A. K., Kaplan M. H., Goswami R. By Journal of Immunology 204 1201-1213 (2020)
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Differential Gene Expression Analysis in 1,25(OH)2D3 treated Human Monocytes establishes link between AIDS Progression, Neurodegenerative disorders, and Aging Biswas B., Goswami R. By Meta Gene - (2021)
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Rheumatoid Arthritis: melting pot of T helper subsets Vyas S. P., Hansda A. K., Goswami R. By International Reviews of Immunology 212-231 (2019)
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A Decade of Th9 Cells: Role of Th9 Cells in Inflammatory Bowel Disease Vyas S. P., Goswami R. By Frontiers in Immunology 9 - (2018)
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Size-dependent cellular uptake and TLR4 attenuation by gold nanoparticles in lung adenocarcinoma cells Vyas S. P., Goswami R. By Nanomedicine 14 229-253 (2019)
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STAT Transcription Factors in T Cell Control of Health and Disease Goswami R., Kaplan M. H. By International review of Cell & Molecular Biology 331 123-180 (2017)
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Striking the right immunological balance prevents progression of tuberculosis Vyas S. P., Goswami R. By Inflammation Research 66 1031-1056 (2017)
Principal Investigator
- Macrophage polarization in colorectal inflammation: A study
of intervention by Vitamin D and Short Chain Fatty Acids
- The Transcription Factors Hox Required for Animal Development, Elucidates a Novel Mechanism of Regulating Th17 and Th9 Cell Differentiation
Co-Principal Investigator
- Institute Small Animal House IIT KHARAGPUR
Ph. D. Students
Arman Kunwar Hansda
Area of Research: Immunology
Biswajit Biswas
Area of Research: Immunology
Sayantee Hazra
Area of Research: Immunology
Shagnik Chattopadhyay
Area of Research: Immunology
Supratik Nandan
Area of Research: Immunology
Swayam Prava Mansingh
Area of Research: Immunology
