Bio Science

No Record Found.

Book Chapter/Section
• Nuclear Magnetic Resonance Spectroscopy to Analyse Protein Folding and Dynamics Saibo N., Boral S. , Saha R. , Das A. K., De S. By Protein Folding Dynamics and Stability 61-81 (2023)
• Analysis of structure and dynamics of intrinsically disordered regions in proteins using solution NMR methods Saibo N.V., Maiti S., Acharya B., De S. By Advances in Protein Molecular and Structural Biology Methods 535-550 (2022)
• Lineshape Analysis as a Tool for Probing Functional Motions at Biological Interfaces De S., Greenwood A. I., Acevedo L. A., Korson N. E., Nicholson L. K. By NMR Spectroscopy for Probing Functional Dynamics at Biological Interfaces 82-121 (2022)
Educational Package
• Experimental Biochemistry Dasgupta S., De S. By - (2023)
• Experimental Biochemistry Dasgupta S., De S. By - (2022)
• Experimental Biochemistry Dasgupta S., De S. By - (2019)
Journal
• Thermodynamics of the association of aminoglycoside antibiotics with human angiogenin. Panda A., Halder K. , Debkumar D. , De S. , Dasgupta S. By Protein & Peptide Letters - (Accepted/In-Press)
• Extein residues regulate the catalytic function of Spl DnaX intein enzyme by restricting the near attack conformations of the active site residues Boral S., Sen S. , Kushwaha T. , Inampudi K. K., De S. By Protein Science - (Accepted/In-Press)
• Non-enzymatic glycation of human angiogenin: Effects on enzymatic activity and binding to hRI and DNA Panda A., Sabnam K., De S., Dasgupta S. By Biochimie - (2023)
• Thermodynamics of the Association of Aminoglycoside Antibiotics with Human Angiogenin Panda A., Halder K., Debnath D., De S., Dasgupta S. By Protein and Peptide Letters 30 92-101 (2023)
• Crystal structure of a mycobacterial secretory protein Rv0398c and in silico prediction of its export pathway Saha R., Mukherjee S. , Singh B. , De S. , Weiss M. S., Das A. K. By Biochemical and Biophysical Research Communications 672 45-53 (2023)
• beta-cyclodextrin encapsulation of curcumin elicits an altered mode of angiogenin inhibition: In vitro and in vivo studies Panda A., Roy P., Goon D., Kottala H., De S., Dasgupta S. By International Journal of Biological Macromolecules 208 654-666 (2022)
• Enhancement of angiogenin inhibition by polyphenol capped gold nanoparticles Panda A., Karhadkar S. , Acharya B. , Banerjee A. , De S. , Dasgupta S. By Biopolymers - (2021)
• Structural and dynamic studies of the human RNA binding protein RBM3 reveals the molecular basis of its oligomerization and RNA recognition Roy S., Boral S. , Maiti S. , Kushwaha T. , Basak A. J., Lee W. , Basak A. , Gholap S. L., Inampudi K. K., De S. By The FEBS journal - (2021)
• Identification of potential short linear motifs (SLiMs) in intrinsically disordered sequences of proteins by fast time-scale backbone dynamics Maiti S., De S. By Journal of Magnetic Resonance Open - (2021)
• Molecular Details of a Salt Bridge and Its Role in Insulin Fibrillation by NMR and Raman Spectroscopic Analysis Ratha B. N., Kar R. K., Bednarikova Z. , Gazova Z. , Kotler S. S., Raha S. , De S. , Maiti N. C., Bhunia A. By The Journal of Physical Chemistry B 124 1125-1136 (2020)
• Characterization of active/binding site residues of peptidyl-tRNA hydrolase using biophysical and computational studies Kulandaisamy R., Kushwaha T. , Kumar V. , De S. , Kumar S. , Upadhyay S. K., Kumar M. , Inampudi K. K. By International Journal of Biological Macromolecules 159 877-885 (2020)
• Structural, Dynamic, and Functional Characterization of a DnaX Mini-intein Derived from Spirulina platensis Provides Important Insights into Intein-Mediated Catalysis of Protein Splicing Boral S., Maiti S. , Basak A. J., Lee W. , De S. By Biochemistry 59 4711-4724 (2020)
• Structural Insights into N-terminal IgV Domain of BTNL2, a T Cell Inhibitory Molecule, Suggests a Non-canonical Binding Interface for Its Putative Receptors Basak A. J., Maiti S. , Hansda A. , Mahata D. , Duraivelan K. , Kundapura . V., Lee . , Mukherjee G. , De S. , Samanta D. By Journal of Molecular Biology 432 5938-5950 (2020)
• Dynamic Studies on Intrinsically Disordered Regions of Two Paralogous Transcription Factors Reveal Rigid Segments with Important Biological Functions Maiti S., Acharya B. , Sheersh Boorla V. , Manna B. , Ghosh A. , De S. By Journal of Molecular Biology 431 1353-1369 (2019)
• Structural characterization of VapB46 antitoxin from Mycobacterium tuberculosis: insights into VapB46 DNA binding Roy M., Kundu A. , Bhunia A. , Das Gupta S. , De S. , Das A. K. By The FEBS journal 286 1174-1190 (2019)
• Cyclic cis-Locked Phospho-Dipeptides Reduce Entry of AbetaPP into Amyloidogenic Processing Pathway Fisher C. L., Resnick R. J., De S. , Acevedo L. A., Lu K. P., Schroeder F. C., Nicholson L. K. By Journal of Alzheimer's Disease 55 391-410 (2017)
• Autoinhibition of ETV6 DNA-binding is established by the stability of its inhibitory helix De S., Okon M. , Graves B. , Mcintosh L. By Journal of molecular biology 428 1515-1530 (2016)
• The Modular Structure of the Inner-Membrane Ring Component PrgK Facilitates Assembly of the Type III Secretion System Basal Body Julien RC Bergeron, Liam J Worrall, Soumya De, Nikolaos G Sgourakis, Adrienne H Cheung, Emilie Lameignere, Mark Okon, Gregory A Wasney, David Baker, Lawrence P McIntosh, Strynadka Natalie CJ By Structure 23 - (2015)
• Steric mechanism of auto-inhibitory regulation of specific and non-specific DNA binding by the ETS transcriptional repressor ETV6 De S., Chan A. C., Coyne H. J., Bhachech N. , Hermsdorf U. , Okon M. , Murphy M. E., Graves B. J., Mcintosh L. P. By Journal of molecular biology 426 1390-1406 (2014)
• Structural Characterization of the C3 Domain of Cardiac Myosin Binding Protein C and Its Hypertrophic Cardiomyopathy-Related R502W Mutant Xiaolu Linda Zhang, Soumya De, Lawrence P McIntosh, Mark Paetzel By Biochemistry 53 - (2014)
• TCR scanning of peptide/MHC through complementary matching of receptor and ligand molecular flexibility William F Hawse, Soumya De, Alex I Greenwood, Linda K Nicholson, Jaroslav Zajicek, Evgenii L Kovrigin, David M Kranz, K Christopher Garcia, Brian M Baker By The Journal of Immunology 192 - (2014)
• Putting a Stop to l,d-Transpeptidases De S., Mcintosh L. P. By Structure 20 753-754 (2012)
• Autoinhibition of ETV6 (TEL) DNA binding: appended helices sterically block the ETS domain H Jerome Coyne, Soumya De, Mark Okon, Sean M Green, Niraja Bhachech, Barbara J Graves, Lawrence P McIntosh By Journal of molecular biology 421 - (2012)
• Complete thermodynamic and kinetic characterization of the isomer-specific interaction between Pin1-WW domain and the amyloid precursor protein cytoplasmic tail phosphorylated at Thr668 De S., Greenwood A. I., Rogals M. J., Kovrigin E. , Lu K. P., Nicholson L. K. By Biochemistry 51 - (2012)
• Complete determination of the Pin1 catalytic domain thermodynamic cycle by NMR lineshape analysis Alexander I Greenwood, Monique J Rogals, Soumya De, Kun Ping Lu, Evgenii L Kovrigin, Linda K Nicholson By Journal of biomolecular NMR 51 - (2011)
• Structural biology: The twist in Crk signaling revealed Nicholson L. K., De S. By Nature Chemical Biology 7 5-6 (2010)
• Elucidation of a pH-folding switch in the Pseudomonas syringae effector protein AvrPto Jennifer E Dawson, Jolita Seckute, Soumya De, Samuel A Schueler, Aaron B Oswald, Linda K Nicholson By Proceedings of the National Academy of Sciences 106 - (2009)
• 3'-N-Alkylamino-3'-deoxy-ara-uridines: A new class of potential inhibitors of ribonuclease A and angiogenin Maiti T. K., De S. , Dasgupta S. , Pathak T. By Bioorganic & medicinal chemistry 14 1221-1228 (2006)
• A docking interaction study of the effect of critical mutations in ribonuclease a on protein ligand binding Mukherjee S., De S. , Ghosh Z. , Dasgupta S. By Biochemistry and Molecular Biology Education 33 335-343 (2005)
Conferences
• Structural and dynamic investigations of murine BTNL2, an orphan T cell co-inhibitor Basak A. J., Maiti S. , Hansda A. , Mukherjee G. , De S. , Samanta D. By 27th conference of the National Magnetic Resonance Society (NMRS 2022) - (2022)
• Understanding the structural basis of protein splicing mechanism mediated by Spl DnaX intein enzyme using solution NMR spectroscopy and molecular dynamics simulations Boral S., Kushwaha T. , Inampudi K. K., De S. By IBS: 44th annual meeting of the Indian Biophysical Society - (2022)
• Understanding the Catalytic Mechanism of Spl DnaX Intein mediated Protein Splicing guided by Solution NMR Spectroscopy and Molecular Dynamics Simulations Boral S., Kushwaha T. , Inampudi K. K., De S. By 35th Annual Symposium of the Protein Society - (2021)
• Elucidating the Role of Protein Partnerships in Modulating DNA Binding Specifi city of Transcription Factors Acharya B., Maiti S. , Basak A. J., De S. By 33rd Annual Symposium of The Protein Society - (2019)
• The Role of dynamics in transcription factor DNA-binding specificity Sheu K., De S. , Mcintosh L. By 33rd Annual Symposium of The Protein Society - (2019)
Symposium
• Understanding the Structural Basis of Protein Splicing Mechanism mediated by Spl DnaX Intein Enzyme using Solution NMR Spectroscopy and Molecular Dynamics Simulations Boral S., Kushwaha T. , Inampudi K. K., De S. By NMRS: 27th annual meeting of the National Magnetic Resonance Society - (2022)
• Structural Characterization by Solution NMR Spectroscopy of a DnaX Mini-intein Derived from Spirulina platensis Boral S., Lee W. , De S. By PDB50: A special symposium celebrating the 50th anniversary of the Protein Data Bank - (2021)
• Solution state structural and dynamic studies of mouse BTNL2, an orphan T cell coinhibitory molecule Basak A. J., Maiti S. , Hansda A. , Mahata D. , Lee W. , Mukherjee G. , De S. , Samanta D. By 33rd Annual Symposium of The Protein Society 152-152 (2019)
Patent
• Alzheimer's disease therapeutics based on pin-1 catalyzed conformational changes in phosphorylated amyloid precursor protein Lu K. P., Nicholson L. K., Pastorino L. , Zhou X. , De S. By - (2008)

Principal Investigator

• Investigating the Molecular Mechanisms of Functional Regulation and DNA-Binding Specificity in the HOX Transcription Factors
• Dissecting the Roles of DNA-Binding Autoinhibition , Post-Translational Modification and Protein Partnerships in the Regulation of the HOX Transcription Factors HOXA9 and HOXB4