We are new group focusing on different aspects of infectious intracellular protozoan pathogens using Leishmania, Toxoplasma and Plasmodium as model system. My research has always focused on different immunological and cellular aspects of parasite biology, that enables these intracellular pathogens to survive within the hostile host enviornment. My scholarship has rendered around theories and methods of protozoan parasitic diseases with applications to clinical importance. We have contributed significantly in the field of drug resistance leishmaniasis one of the major emerging problem for India with new cases reported every year. For a better understanding of protozoan mediated infectious disease I started working on Plasmodium and Toxoplasma causative agents of Malaria & Toxoplasmosis as an EMBO-Post-doctoral fellow. My post-doctoral scholarship primarily articulate in successfully characterized key factors involved in establishing successful infection and dissemination of apicomplexan parasites into or out of the host. During this peroid I also managed a collaborative project with industrial partner UCB Pharma S.A and Medicines for Malaria Venture (MMV) to design biochemical assays for therapeutic development.
My research interest is interdisciplinary in nature, and our lab want to explore the possibility to establish a potent CRISPR-Cas9 based genome editing techniques in protozoan biology, which in turn could be implemented in characterization of key components of disease pathogenesis & intra/inter species-transmission of these intracellular pathogens. Another focus of the lab would be to develop biochemical assays for activity-based protein profiling to study parasite biology with a particular view of developing them with potential translational value for pharma industries. This should also serve as the base to challenge the existing problem of drug resistance and absence of vaccine, and help in designing of novel drug targets against these pathogens which currently is affecting a huge part of population each year.
Visit Us at: https://molecularparasitol.wixsite.com/idi-lab
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A Novel Bioimpedance-Based Detection of Miltefosine Susceptibility Among Clinical Leishmania donovani Isolates of the Indian Subcontinent Exhibiting Resistance to Multiple Drugs Ghosh S., Biswas S., Mukherjee S., Pal A., Saxena A., Sundar S., Dujardin J.-C., Das S., Roy S., Mukhopadhyay R., Mukherjee B. By Frontiers in Cellular and Infection Microbiology 11 - (2021)
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Antimony resistant Leishmania donovani upregulates IL-10 to overexpress host multi drug resistant protein1 Mukherjee B., Mukhopadhyay R. , Bannerjee B. , Chowdhury S. , Naskar K. , Allam U. , Chakravortty D. , Sundar S. , Dujardin J. , Roy S. By Proc Natl Acad Sci U S A 110(7) 575-582 (2013)
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Linking membrane fluidity with defective antigen presentation in leishmaniasis Pradhan S., Ghosh S., Hussain S., Paul J., Mukherjee B. By Parasite Immunology - (2021)
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Role of chromatin modulation in the establishment of protozoan parasite infection for developing targeted chemotherapeutics Ghosh S., S. , Hussain . , Makkar . , Mukherjee B. By The Nucleus 1-13 (2021)
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Structural insights into an atypical secretory pathway kinase crucial for Toxoplasma gondii invasion Lentini G., Chaabene . B., Vadas . , Ramakrishnan . , Mukherjee B. , Mehta V. , Lunghi M. , Grossmann . , Maco B. , Visentin R. , Hehl A. B., Korkhov . M., Soldati-favre D. By Nature Communication - (2021)
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Probing the molecular mechanism of aggressive infection by antimony resistant Leishmania donovani Mukherjee B., Mukherjee K. , Nanda P. , Mukhopadhayay R. , Ravichandiran V. , Bhattacharyya S. , Roy . By Cytokine 10.1016/j.cyto.2020.155245 - (2020)
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Short-Course Treatment With Imipramine Entrapped in Squalene Liposomes Results in Sterile Cure of Experimental Visceral Leishmaniasis Induced by Antimony Resistant Leishmania donovani With Increased Efficacy Mukherjee S., Pradhan S., Ghosh S., Sundar S., Das S., Mukherjee B., Roy S. By Frontiers in Cellular and Infection Microbiology 10 - (2020)
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Modeling and resistant alleles explain the selectivity of antimalarial compound 49c towards apicomplexan aspartyl proteases Mukherjee B., Tessaro F. , Vahokoski J. , Kursula I. , Marq J. , Scapozza L. , Soldati-favre D. By EMBO J 37(7) 98047-98062 (2018)
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A drugable secretory protein maturase of Toxoplasma essential for invasion and egress Dogga S. K., Mukherjee B. , Jacot D. , Malino L. , Hammoudi P. , Hartkoorn R. , Hell A. , Soldat-favre D. By Elife 6 27480- (2017)
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A multi-stage antimalarial targets the plasmepsins IX and X essential for invasion and egress Pino P., Caldelari R. , Mukherjee B. , Vahokoski J. , Klages N. , Maco B. , Collins C. ., Blackman M. J., Kursula I. , Heussler V. , Brochet M. , Soldati-favre D. By Science 358(6362) 522-528 (2017)
Principal Investigator
- CRISPR-Cas based Rapid Diagnostics of Miltefosine Susceptible and Resistant Strains of Leishmania Donovani from Asymptomatic and Post Kala Azar Dermal Leishmaniasis using Invasive and Non-invasive approach
Co-Principal Investigator
- Community-based Intervention to address Antibiotic Resistance: An embedded mixed-methods interventional study INDIAN COUNCIL OF MEDICAL RESEARCH (ICMR)
- Comparative Assessment of the Neutralization Efficacy of Indigenous Vaccines against Prevailing Variants of Concerns of SARS-Cov-2 Circulating in India Indian Council of Medical Research, Dept. of Health Research, Ministry of Health and Family Welfare
- Mechanistic investigation of the
complex inter-relationship between HbE/Beta-thalassemia and protozoan parasite infections with HLA
association Indian Council of Medical Research (ICMR)
Ph. D. Students
Debolina Manna
Area of Research: Infectious disease and immunology
Deepak K
Area of Research: Cancer Biology
Rishika Jana
Area of Research: Biochemistry of Leishmania parasite
Saikat Biswas
Area of Research: Polymer and Tissue Engineering
Shatarupa Bhattacharya
Area of Research: Application of molecular biology approaches for disease management
Shreya Banerjee
Area of Research: Cancer Biology
Shubhangi Chakraborty
Area of Research: Infectious disease and immunology
Snehlata
Area of Research: Infectious disease and immunology
Souradeepa Ghosh
Area of Research: Infectious disease and immunology
Supratim Pradhan
Area of Research: Infectious disease and immunology
