BioMEMS is a rapidly advancing, inter-disciplinary research field for creation and development of new methods/systems to effectively process or manipulate biological materials with electronic devices and components. Giving a prior importance to the biomedical sensing research, an interdisciplinary R&D work at School of Medical Science and Technology, IIT Kharagpur has been initiated to promote MEMS and Biosensor activity that encompasses design, fabrication and engineering of biomedical & microfluidic devices for its electro-physiological characterisation. For the evaluation of electrical and physical properties of biomolecules and cells using suitable micro-fluidic devices, appropriate fabrication of polymeric coated bio-MEMS are being investigated and its utility are evaluated under different microscopic and electrical impedance study. The research also involves development of different BioMEMS transducers and related technologies for sensing various biomedical signals for precise and appropriate diagnostics and therapeutics. Microfabrication technology is being explored to develop various miniature MEMS devices for deployment of in-vivo and in-vitro detection of biomedical signals and its characterisation.
Presently, the following activities are being pursued:
- Development of MEMS based flow sensor on flexible substrate - Realization of a polymer (PDMS) based cardiovascular shear stress/ flow sensor using micro fabrication techniques on catheter to monitor real-time blood flow for atherosclerosis diagnosis satisfying sensitivity, biocompatibility and reliability requirements. The major aim of this research is to develop catheter-based MEMS sensors to provide high spatial and temporal resolution for real-time monitoring in the vasculature.
Separation and manipulation of cells on Microfluidic Platform by Dielectrophoresis - Realization of an integrated microfluidic device with planer electrodes for rapid and continuous separation of biological cells in mixed cell population with high selectivity using dielectrophoresis technique.
MEMS based Biosensor for Electrophysiological characterization of cells – Electrical impedance spectroscopy (EIS) is used to study the electrochemical phenomena in cells and the toxicological effects in cells.
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Fibril growth captured by electrical properties of amyloid-beta and human islet amyloid polypeptide Awasthi P., Singh A. , Khatun S. , Gupta A. N., Das S. By Physical Review E 101 062413- (2020)
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Coronavirus disease 2019 (COVID-19) outbreak: some serious consequences with urban and rural water cycle Bhowmick G. D., Dhar D. , Nath D. , Ghangrekar M. M., Banerjee R. , Das S. , Chatterjee J. By Clean Water 3 - (2020)
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In vivo performance analysis of silanized and coated nitinol wires in biological environment Sinha S., Priyadarshani J. , Devi K. B., Kishore A. V., Das P. , Chanda A. , Das S. , Roy M. , Nandi S. K. By Journal of Materials Research 35 1262-1270 (2020)
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Mapping of biomechanical properties of cell lines on altered matrix stiffness using Atomic Force Microscopy Wala J., Das S. By Biomechanics and Modeling in Mechanobiology - (2020)
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Cost-effective fabrication of ionic polymer based artificial muscles for catheter-guidewire maneuvering application Tripathi A. S., Chattopadhyay B. P., Das S. By Microsystem Technologies 25 1129-1134 (2019)
Principal Investigator
- Bio-inspired Large Area Conformal and Flexible Sensors for Biomedical and Robotic Applications
- Building the Evidence Base for Maternal Immunization to Protect Indian Infants from Lower Respiratory Tract Infections
- Nano-electronics Network for Research and Application (NNetRA)- IIT Kharagpur (MEITY Part)
- Nano-electronics Network for Research and Applications (NNetRA)- IIT Kharagpur (DST Part)
- Usage charges for facilities under INUP i2i and NNetRA projects
Co-Principal Investigator
- Label-Free Detection Of Circulating Exhausted CD8+ T
Cells Using Raman Spectroscopy In Murine Models Of
Metastatic And Non-Metastatic Cancer Science and Engineering Research Board (SERB)
Ph. D. Students
Abhijit Lincon
Area of Research: Biomicrofluidics and electrochemical sensors
Akashlina Tarunkanti Basu
Area of Research: Flexible biomedical sensor
Anjali
Area of Research: Microfluidics for biochemical analysis
Arijit Pal
Area of Research: Biomedical Sensor development
Asmita Das
Area of Research: Cancer Biology
Biswadeep Roy
Area of Research: Microfluidics
Dhruba Dhar
Area of Research: Nanomaterial based molecular imaging and microfluidics
Pooja C Asani
Area of Research: Development of a multiplexed autoantibody sensor for Type 1 Diabetes diagnostics
Pratyusa Mohapatra
Area of Research: nanobiosensor
Priyanka Choudhury
Area of Research: Biomarkers
Sandeep Kumar Yadav
Area of Research: Microfluidic devices and Nanomaterial based drug design
Sayori Biswas
Area of Research: Nanomaterial based devices for biosensing
Shiv Prakash Verma
Area of Research: Flexible and Stretchable Electronics
Shreyasi Das
Area of Research: Nanomaterial based biosensing
Shubhangi Das
Area of Research: organ on chip for vascular disease
Shyamal Mandal
Area of Research: Nanotechnology
Smriti Sinha
Area of Research: Biosensors and biomicrofluidics
Souvik Biswas
Area of Research: Biosensors
Swachhatoa Ghosh
Area of Research: Flexible biomedical sensor