If life is a story, then genetics is its language. Surprisingly, the script for this language, has only four alphabets (A, G, C and T for DNA and A, G, C and U for RNA). This simplicity ingrained in the most complex language of the mortal world has always baffled me as a scientist. I am primarily interested in decrypting the script of life and mastering it modulate health and disease. Decoding the secret language will allow us to develop newer strategies to counter pathophysiological challenges in human beings by encoding and packaging new information in life’s own language. My earlier work involved studying the role of small RNA molecules (known as microRNAs) in the interactions of bone cells with microroughened titanium implant surfaces. Presently I am developing a research lab in the field of regenerative medicine wherein I’ll be using molecular biology tools to study human pathophysiological conditions and attempt to identify therapeutic tools.
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Comparison of oral dydrogestrone with progesterone gel and micronized progesterone for luteal support in 1,373 women undergoing in vitro fertilization: a randomized clinical study Ashalatha Ganesh, Nishant Chakravorty, Rashmi Mukherjee, Sourendrakanta Goswami, Koel Chaudhury and Baidyanath Chakravarty By Fertility and Sterility 95 (6) 1961-5 (2011)
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Analyzing microRNA mediated regulation of fetal hemoglobin in beta-thalassemia using miRnalyze, a novel bioinformatics tool Das S. S., James M. , Paul S. , Chakravorty N. By Scientific Devices, Technology Applications & Community Linkage - (2017)
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Methods in Molecular Biology by Yinghong Zhou, Nishant Chakravorty, Yin Xiao and Wenyi Gu By Mesenchymal stem cells and nano-structured surfaces 133-48 (2013)
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Alteration of the C-terminal ligand specificity of the Erbin PDZ domain by allosteric mutational effects Javier Murciano-Calles, Megan E. McLaughlin, Ariel Erijman, Yogesh Hooda, Nishant Chakravorty, Jose C. Martinez, Julia M. Shifman and Sachdev S. Sidhu By Journal of Molecular Biology 426 (21) 3500-8 (2014)
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Pro-osteogenic topographical cues promote early activation of osteoprogenitor differentiation via enhanced TGFβ, Wnt and Notch signaling by Nishant Chakravorty, Stephen Hamlet, Anjali Jaiprakash, Ross Crawford, Adekunle Oloyede, Mohammed Alfarsi, Yin Xiao and Saso Ivanovski By Clinical and Oral Implants Research 25 (4) 475-86 (2014)
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Lithium release from β-tricalcium phosphate inducing cementogenic and osteogenic differentiation of both hPDLCs and hBMSCs Pingping Han, Mengchi Xu, Jiang Chang, Nishant Chakravorty, Chengtie Wu and Yin Xiao By Biomaterials Science (9) 1230-43 (2014)
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Computational pharmacokinetics and in vitro-in vivo correlation of anti-diabetic synergistic phyto-composite blend Baishakhi De, Koushik Bhandari, Nishant Chakravorty, Ranjan Mukherjee, Rohit Gundamaraju, Rajeev K Singla, Prakash Katakam, Shanta K Adiki, Biswajoy Ghosh, Analava Mitra By World Journal of Diabetes 6 (11) 1179-85 (2015)
Principal Investigator
- A Biomimetic ECM Protein-based Bioadhesive Graft Copolymer for Implants - Targeting Enhanced Soft Tissue Integration and Osseointegration
- Mechanistic investigation of the
complex inter-relationship between HbE/Beta-thalassemia and protozoan parasite infections with HLA
association
- MicroRNA based Reprogramming of Fetal Hemoglobin in Beta-Thalassemia
Co-Principal Investigator
- Development of customized implants via powder metallurgy process Science and Engineering Research Board (SERB)
Ph. D. Students
Dipanjana Ghosh
Area of Research: Mechanistic insights into Beta-thalassemia and complications
Lopa Mudra Das
Area of Research: Development of a bioadhesive material for medical applications
Mandrita Mukherjee
Area of Research: Genetic modifiers of beta-thalassemia
Motiur Rahaman
Area of Research: New Approaches to Manage Beta-thalassemia
Murali Mohan Mishra
Area of Research: Lipid Nanomaterials
Prasanna Kumar Byram
Area of Research: Tissue Engineering
Shatarupa Bhattacharya
Area of Research: Application of molecular biology approaches for disease management
Sricheta Parui
Area of Research: Human Computer Interaction
Subhangi Basu
Area of Research: Beta-thalassemia and Cardiovascular complications
Sudip Dey
Area of Research: Epigenetic regulators in Beta-thalassemia
Surajit Kundu
Area of Research: Medical Image Processing