I am interested in doing research in the field of Biophysics of proteins (mostly on intrinsically disordered proteins) and DNA . How biological molecules fold (and unfold) is a question of immense importance in both the physical sciences and life sciences. The single-molecule experiments offer several advantages over conventional ensemble methods through the removal of ensemble averaging. By conducting many sequential measurements the distributions and fluctuation of molecular properties can be characterized, transient intermediates can be revealed. Single-molecule trajectories provide dynamic and statistical information that is often hidden in ensemble-averaged results and also permit real-time observation of rarely populated transients, which is difficult or impossible to capture using conventional methods.
Free-energy landscape formalisms provide the fundamental conceptual framework for understanding of the biophysics of folding: in principle, the microscopic rates, diffusion constant at different point of the landscape and pathways for folding of protein. Theoretical studies suggest that single-molecule experiments, performed at different temperatures, might allow exploration of the roughness of protein-folding energy landscapes. It would be nice to explore this aspect from the energy landscape profile. I am always kin to learn new techniques to explore more in the field of Biophysics to improve our understanding of living world.
Principal Investigator
- Early Diagnosis of Infection Biomarkers (human neutrophil elastase (HNE) and cathepsin G (CatG)) in Wound Fluid based on Textile-based Embroidered Biosensors
Co-Principal Investigator
- Elucidating Ca2+/CaM-master regulator(s) and their potential target proteins in rice aiming at abiotic stress mitigation Science and Engineering Research Board (SERB)
Ph. D. Students
Akshay Narayan Sarangi
Area of Research: Biophysics and Soft Matter Physics
Debdip Brahma
Area of Research: Biophysics and Soft Matter Physics
Debendra Majhi
Area of Research: Biophysics
Rupal Kaushik
Area of Research: Biophysics, application of nano-materials
Utkarsh Sinha
Area of Research: Computational Biophysics
MS Students
Amit Kumar Mondal
Area of Research: atomic and molecular simulations
