Research Interests
Our lab work at the interface of organic synthesis and chemical biology. We are interested in the synthesis of chemically modified oligonucleotides (ASOs, siRNAs, aptamer, etc.) and testing their biochemical properties. We synthesize chemically modified oligonucleotides to improve stability, cellular uptake, and potency in therapeutic applications. Few projects are in the pipeline, such as synthesis and applications of fluorescent nucleosides to study nucleic acid interactions, targeted delivery of siRNAs, etc. We are also involved in the development of turn-on fluorescent probes for the detection of biologically important molecules such as cyanide, biological thiols, heavy metals, etc. In the area of synthetic chemistry, we are developing new methodologies in the synthesis of chemically modified nucleosides, developing optical probes, etc.
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Folate Receptor-Mediated siRNA Delivery: Recent Developments and Future Directions for RNAi Therapeutics Gore K. R., Gangopadhyay S. , Nikam R. R. By Nucleic acid Therapeutics 1 - (2021)
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Synthesis, Gene Silencing, and Molecular Modelling Studies of 4 -C-Aminomethyl-2 -O-Methyl-Modified Small Interfering RNAs Gore K. R., Nawale G. N., Harikrishna S. , Chittoor V. , Pandey S. , Höbartner C. , Patankar S. , Pradeepkumar P. I. By Journal of Organic Chemistry 77 3233-3245 (2012)
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LiHMDS: Facile, Highly Efficient, and Metal-Free Transesterification under Solvent-Free Condition Gore K. R., Mittapelli L. L. By Catalysis Communications 149 106194-106199 (2021)
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Journey of siRNA: Clinical Developments and Targeted Delivery Nikam R. R., Gore K. R. By Nucleic Acid Therapeutics 1 209-224 (2018)
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Novel Silylated HBI Analog for Rapid, Selective, and Sensitive Detection of Cyanide in Water and Living Cells Mirajkar A. L., Mittapelli L. L., Nawale G. N., Gore K. R. By Sensors and actuators B: Chemical 265 257-263 (2018)
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large Stokes shift fluorogen-activating RNA aptamer Steinmetzger C., Palaniswamy N. , Gore K. R., Höbartner C. By Chemistry-European Journal 25 1931-1935 (2019)
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The N2-Furfural Deoxyguanosine (fdG) Adduct Does Not Alters The Structure of B-DNA Ghodke P., Gore K. R., Harikrishna S. , Samanta B. , Kottur J. , Nair D. T., Pradeepkumar P. I. By Journal of Organic Chemistry 81 502-511 (2016)
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Influence of 2 -Fluoro versus 2 -O-Methyl Substituent on the Sugar Puckering of 4 -C-Aminomethyl-uridine Gore K. R., Harikrishna S. , Pradeepkumar P. I. By Journal of Organic Chemistry 78 9956-9962 (2013)
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Incorporation of 4'-C-Aminomethyl-2'-O-Methylthymidine into DNA by Thermophilic DNA Polymerases Nawale G. N., Gore K. R., Höbartner C. , Pradeepkumar P. I. By Chemical Communications 48 9619-9621 (2012)
Principal Investigator
- Carrier-Free Folate-siRNA Conjugates Bearing Diverse 4-C-Alkylamino-2-Fluoro-Pyrimidines to Evaluate the Targeted Delivery and Synergistic Gene Silencing in Cancers
- Synthesis and Biological Studies of Novel 2 4 Dual and 2 Mono Chemical Modifications for Potential Applications in Antisense Technology
Co-Principal Investigator
- Development of thermally stable additives and high performance water-based drilling fluids up to 230 C OIL AND NATURAL GAS CORPORATION LIMITED
Ph. D. Students
Avijit Sahoo
Area of Research: Nucleic acid chemistry
Dola Dev
Area of Research: Bio organic Chemistry
Gourav Das
Area of Research: Bioorganic Chemistry
Nishant Kumar Choudhary
Area of Research: Nucleic acid chemistry
Pritam Rakshit
Area of Research: Bio organic Chemistry
Rahul Kumar
Area of Research: Bio organic Chemistry
Santanu Sar
Area of Research: Nucleic acid chemistry
Sumit Gangopadhyay
Area of Research: Bio organic Chemistry