“The ideal synthesis creates a complex skeleton..in a sequence only of successive construction reactions involving no intermediary. Refunctionalization, and leading directly to the structure of the target, not only its skeleton but also its correctly placed functionality.”[Hendrickson, J. B. J. Am. Chem. Soc. 1975, 97, 5784.] The outlook of synthetic organic chemistry is changing very rapidly. But one feature is still unique to all molecular architects i.e. the ability to design and development of new molecules. Basically, the pathways to achieve the targets are changing in synthetic organic chemistry. The challenges posed by pharmaceutical, biology and material science seek attention from synthetic chemist to provide faster, economic and environmentally acceptable solutions. Catalysis, especially transition metal catalysis has taken a lead role to provide architecturally complex molecules in more faster, milder and simpler way. We are involved in developing new transition metal catalysed synthetic technology and late stage functionalization of complex molecules. We are using these protocols to make strategies that enable the rapid formation of library of complex, unprecedented structure which can be further examined for unexplored biological properties. Another field of interest is to furnish the complete architecture of biologically active natural products using inert bond activation strategy.
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Cu(II)-Catalyzed Construction of Heterobiaryls using 1-Diazonaphthoquinones: A General Strategy for the Synthesis of QUINOX and Related P,N Ligands Biswas A., Pan S., Samanta R. By Organic Letters 24 1631-1636 (2022)
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Copper Catalyzed Regioselective Cascade Alkylation and Cyclocondensation of Quinoline N-Oxides with Diazo esters: Direct Access to conjugated -Systems Biswas A., Karmakar U. , Pal A. , Samanta* R. By Chem A Eur J 22 13826-13830 (2016)
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Rh(III)-Catalyzed Weakly Coordinating 2-Pyridone-Directed Oxidative Annulation Using Internal Alkynes: A Reversal in Selectivity Bera S., Sarkar S., Pal J., Samanta R. By Organic Letters 24 8470-8475 (2022)
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Weakly Coordinating tert-Amide Assisted Ru(II)-Catalyzed Synthesis of Azacoumestans via Migratory Insertion of Quinoid Carbene: Application in Total Synthesis of Isolamellarins Sarkar S., Samanta R. By Organic Letters 24 4536-4541 (2022)
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Iridium(III)-Catalyzed Intermolecular Mild N-Arylation of Aliphatic Amides Using Quinoid Carbene: A Migratory Insertion-Based Approach Bera S., Roy S., Pal S.C., Anoop A., Samanta R. By ACS Catalysis 11 10847-10854 (2021)
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Rh(iii)-Catalyzed mild straightforward synthesis of quinoline-braced cyclophane macrocycles: Via migratory insertion Ghosh B., Bera S., Ghosh P., Samanta R. By Chemical Communications 57 13134-13137 (2021)
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Rh(iii)-Catalyzed tandem indole C4-arylamination/annulation with anthranils: Access to indoloquinolines and their application in photophysical studies Biswas A., Bera S., Poddar P., Dhara D., Samanta R. By Chemical Communications 56 1440-1443 (2020)
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Rh(iii)-Catalyzed straightforward arylation of 8-methyl/formylquinolines using diazo compounds Ghosh B., Samanta R. By Chemical Communications 55 6886-6889 (2019)
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Direct Pd(II)-Catalyzed Site-Selective C5-Arylation of 2-Pyridone Using Aryl Iodides Maity S., Das D. , Sarkar S. , Samanta* R. By Organic Letters 20 5167-5171 (2018)
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Regiocontrolled Direct C4 and C2-Methyl Thiolation of Indoles under Rhodium Catalyzed Mild Conditions Maity S., Karmakar U. , Samanta* R. By Chem. Commun. 53 12197-12200 (2017)
Principal Investigator
- Design and Synthesis of Benzophenanthroline Based Axially Chiral Ligands: Applications in Stereoselective Synthesis using Diazo Compounds
- Transition Metal Catalyzed Construction of 2-Pyridone Based Extended Conjugated Systems and Macrocycles
Ph. D. Students
Bortika Sanyal
Area of Research: Synthetic Organic Chemistry
Sanhita Sarkar
Area of Research: Synthetic Organic Chemistry
Sarbojit Das
Area of Research: Synthetic Organic Chemistry
Satabdi Bera
Area of Research: Synthetic Organic Chemistry
Souradip Sarkar
Area of Research: Synthetic Organic Chemistry
Souvik Bhadra
Area of Research: Synthetic Organic Chemistry
Subarna Pan
Area of Research: Synthetic Organic Chemistry
Suparna Kundu
Area of Research: Synthetic Organic Chemistry
