Total synthesis of natural products is the most challenging and intriguing area of research in the chemical science related disciplines. In the early 20th century, the field of synthetic organic chemistry, while established in many respects, was to continue a sharp path of progress and advancement for over a century to reach the level of power and sophistication that it possesses today. This is a unique tool for accessing new chemical entities with great biological potential, which seems to be impossible to access from natural sources due to its scarce availability. In our group we focus on the total synthesis of structurally and architecturally complex natural products. The selection of our target molecules is mainly based on strategy driven approach.
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Stereoselective desymmetrization of 2,2-bishydroxymethyl-1-tetralones by iodocyclization, synthesis of novel [6,6,5] tricyclic framework and chemo- enzymatic diversity generation T. Mahapatra, N. Jana and S. Nanda By Adv. Syn. Catal 353 2152-2168 (2011)
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Asymmetric total synthesis of (-)-rasfonin R. Bhuniya and S. Nanda By Tetrahedron 69 1153-1165 (2013)
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Enantiomeric scaffolding of α-tetralone and related scaffolds by EKR (enzymatic kinetic resolution) and stereoselective ketoreduction with ketoreductases R. Bhuniya, T. Mahapatra and S. Nanda By Org. Biomol. Chem 10 536-547 (2012)
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Asymmetric total synthesis of paecilomyci E, 10-epi-paecilomycin E and 6-epi-cochliomycin C P. Pal, N. Jana and S. Nanda By Org. Biomol. Chem 12 8257-8274 (2014)
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Chemoenzymatic asymmetric total synthesis of nonanolide (Z)-cytospolides D,E and their stereoisomers R. Rej and S. Nanda By Eur. J. Org. Chem 860-871 (2014)
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Klebsiella pneumoniae (NBRC 3319) Mediated Asymmetric Reduction ofα-Substituted β-Oxo Esters and Its Application to the Enantioiselective Synthesis of Small-Ring Carbocycle Derivatives R. Bhuniya, T. Mahapatra and S. Nanda By Eur. J. Org. Chem 1597-1602 (2012)
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Asymmetric synthesis of cochliomycin-A and zeaenol N. Jana and S. Nanda By Eur. J. Org. Chem 4313-4320 (2012)
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Stereoselecive synthesis of enantiopure oxetanes, carbohydrate mimic, ε-lactone, and cyclitols from biocatalytically derived β-hydroxyesters as chiral precursors D. Das, J. Halder, R. Bhuniya and S. Nanda By Eur. J. Org. Chem 5229-5246 (2014)
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Asymmetric synthesis of naturally occurring (-)-seimatopolides A and B R. Rej, P. Pal and S. Nanda By Tetrahedron 70 4457-4470 (2014)
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Asymmetric synthesis of naturally occurring nonenolide xyolide through cross metathesis and macrolactonization reaction R. Rej, A. Jana and S. Nanda By Tetrahedron 70 2634-2642 (2014)
Principal Investigator
- Asymmetric total synthesis of topologically distinct alkylidene-butenolide based natural products and its structural congeners
- Synthetic Studies towards Hamigermycins, Hyalodendriellins, Caryospomycins and its Structural Congeners: Novel RALs through a Late Stage Biomimetic Lactonization Approach
Ph. D. Students
Chandan Kumar Soni
Area of Research: Asymmetric total synthesis of complex natural products
Jayanta Das
Area of Research: Asymmetric total synthesis of diterpenoid natural products
Kishor Kumar Mandal
Area of Research: Bimetalic cascacde cyclization and its expploration in compplex naturall pproduct synthesis
Rajarshee Sarkar
Area of Research: Total synthesis of butenolides and related naturall pproducts
Rasmita Barik
Area of Research: Enzymatic reduction in organic synthesis
Santu Bisui
Area of Research: Asymmetric total synthesis of complex natural products
Saubhik Ghosh
Area of Research: Asymmetric total synthesis of diterpenoid natural products
Shrestha Chatterjee
Area of Research: Asymmetric total synthesis of complex natural products
Suman Bhatta
Area of Research: Asymmetric total synthesis of complex natural products
Swagata Das
Area of Research: Asymmetric total synthesis of complex natural products