1) Dual Catalysis & Asymmetric Synthesis: Our research is mainly focused on catalysis to develop new reaction methods. To this end, we are interested to study both transition metal catalysis and organo-catalysis to achieve new reactions in both asymmetric and racemic form. Besides mono catalysis, multi catalysis (dual catalysis) is another major topic in our laboratory. Initially we are working on dual catalysis by merging Lewis acid catalysis (to generate electrophiles) with Cu- or amine catalysis (to generate nucleophiles). Chiral ligands such as N-heterocyclic carbenes, Box, pyBox and phosphines will be used along with a suitable Cu-salt to achieve enantioselectivity. With the success of these methodologies, valuable precursors can be synthesized in a very efficient way.
2) Asymmetric Synthesis: Apart from the above mentioned asymmetric catalysis, auxiliary based asymmetric synthesis is another topic in our laboratory. Here sulfinyl imines are our auxiliary based chiral electrophiles. Thus highly useful structurally diverse chiral amines will be prepared in comparatively short reaction sequences by designing some attractive nucleophiles. Chiral amines are key structural motif and wide spread in many synthetic drugs, natural products and medicinally important molecules. We are also working on the total synthesis of few selective class of bio-active natural products by designing suitable methodologies based on N-sulfinyl imines
3) C-H-Bond Functionalization: In the myriad of transitional metal catalyzed reactions, C-H bond functionalizations is currently one of the frontier fields in the organic synthesis. A rapid development in this topic has been achieved during last few years and many powerful synthetic methods have been reported in the literature. Being very ubiquitous in most of the organic molecules, selective C-H bond functionalization is highly important as that can lead to the access of the functionalized compounds directly from the readily available precursors and hence save both cost as well as time.
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Oxidative Homocoupling of Aryl, Alkenyl, and Alkynyl Grignard Reagents with TEMPO and Dioxygen Maji M. S., Pfeifer T. , Studer A. By Angew. Chem. Int. Ed. 47 9547-9550 (2008)
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Weakly Coordinating Ketone-Directed Cp*Co(III)-Catalyzed C H Allylation on Arenes and Indoles Sk M. R., Bera S. S., Maji M. S. By Organic Letters 20 134-137 (2018)
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Benzannulation of 2-Alkenylindoles using Aldehydes by Sequential Triple-Relay Catalysis: A Route to Carbazoles and Carbazole Alkaloids Banerjee A., Sahu S. , Maji M. S. By Advanced Synthesis and Catalysis 359 1860-1866 (2017)
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Transition-Metal-Free Redox-Neutral One-Pot C3-Alkenylation of Indoles Using Aldehydes Sahu S., Banerjee A. , Maji M. S. By Organic Letters 19 464-467 (2017)
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Cp*CoIII-Catalyzed syn-Selective C-H Hydroarylation of Alkynes Using Benzamides: An Approach Toward Highly Conjugated Organic Frameworks Bera S. S., Debbarma S. , Ghosh A. K., Chand S. , Maji M. S. By The Journal of Organic Chemistry 82 420-430 (2017)
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Cp*Rh(III)-Catalyzed Low Temperature C-H Allylation of N-Aryltrichloro Acetimidamide Debbarma S., Bera S. S., Maji M. S. By The Journal of Organic Chemistry 81 11716-11725 (2016)
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Cp*RhIII-Catalyzed Directed Amidation of Aldehydes withAnthranils Debbarma S., Maji M. S. By European Journal of Organic Chemistry 3699-3706 (2017)
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On the Mechanism and Selectivity of N-triflylphosphoramide Catalyzed (3+2) Cycloaddition between Hydrazones and Alkenes Hong X., Küçük H. B., Maji M. S., Yang Y. , Rueping M. , Houk K. N. By J. Am. Chem. Soc. 136 13769-13780 (2014)
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Asymmetric Brønsted Acid Catalyzed Cycloadditions Efficient Enantioselective Synthesis of Pyrazolidines, Pyrazolines and 1,3-Diamines from N-Acyl Hydrazones and Alkenes Rueping M., Maji M. S., Küçük H. B., Atodiresei I. By Angew. Chem. Int. Ed. 51 12864-12868 (2012)
Principal Investigator
- Asymmetric Total Syntheses of Leuconoxine, Leuconodine A-F, Melodinine E, Rhazinal and Related Alkaloids by Generation of Aldehydes Bearing alpha-All Carbon Quaternary Centre
- Catalytic Asymmetric Di-Functionalization of Enamides by One-Pot Cascade Three-Component Reaction: A Route to Highly Functionalized ���²-Amino Aicds
- Design, Synthesis and Application of Chiral Alkoxyamide Phase-Transfer Catalysts
Ph. D. Students
Abhisek Metya
Area of Research: Catalysis and Organic Synthesis
Arpita Brahma
Area of Research: Catalysis and Organic Synthesis
Arya Bhattacharyya
Area of Research: Design and Synthesis of Organic Semiconducting Materials
Ganesh Karan
Area of Research: Organic Synthesis
Haripriyo Mondal
Area of Research: Asymmetric Catalysis
Minakshi Ghosh
Area of Research: Organic Synthesis
Samrat Kundu
Area of Research: New Reaction Development, Organo-Catalysis
Sharmila Das
Area of Research: Organic Synthesis
Subimal Patra
Area of Research: Organic Synthesis
Susanta Bhunia
Area of Research: Catalysis and Organic Synthesis
