Development of catalytic & asymmetric 1,2-migration of boronate esters for alkene/alkyne functionalization; a new direction in asymmetric synthesis:
We have been interested in developing asymmetric multicomponent coupling reactions to functionalize olefin and alkyne. Asymmetric di-functionalization of olefin, adding two distinct functional groups on each side of the C-C bond, in a single operation is one of the most attractive transformations in organic chemistry. Sharpless di-hydroxylation & amino-hydroxylation; Jacobsen epoxidation and ring opening; are the benchmark reactions for asymmetric functionalization of the alkene. In recent years, few catalytic and asymmetric palladium/copper/rhodium catalyzed alkene functionalization was reported. While some of these reactions are limited to activated alkene or offer narrow functional group tolerance. We are interested in asymmetric, catalytic functionalization of alkene using 1,2-boronate rearrangements
Total synthesis of spiroketal based natural products having cytotoxicity against cancer cell lines
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Palladium Catalyzed Asymmetric Three Component Coupling of Boronic Esters, Indoles and Allylic Acetates Panda S., Ready J. By Journal of American Chemical Society 139 6038-6041 (2017)
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Synthesis and Utility of Dihydropyridine Boronic Esters Panda S., Coffin A. , Nguyen Q. , Tantillo P. , Ready P. By Angew. Chem. Int. Ed. 55 2205-2209 (2016)
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Synthesis of a potential intermediate for TMC-95A via an organocatalyzed aldol reaction Panda S., Pearson A. , Bunge S. By Journal of Organic Chemistry 78 9921-9928 (2013)
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N-prolinylanthranilamide pseudopeptides as bifunctional organocatalysts for asymmetric aldol reactions Panda S., Pearson A. By Organic Letters 13 5548-5551 (2011)
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N-Prolinylanthranilic Acid Derivatives as Bifunctional Organocatalysts for Asymmetric Aldol Reactions Panda S., Pearson A. By Tetrahedron 67 3969-3975 (2011)
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Tandem Allylation/1,2-Boronate Rearrangement for the Asymmetric Synthesis of Indolines with Adjacent Quaternary Stereocenters Panda S., Ready J. By J. Am. Chem. Soc 140 13242-13252 (2018)
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Transition Metal Free Synthesis of Heterobiaryls through 1,2 Migration of Boronate Complex Panda S., Paul S. , Das K. K., Manna S. By Chemistry A European Journal 26 1922-1927 (2020)
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Functionalization of Heterocycles Through 1,2 Metallate Rearrangement of Boron Ate Complex Panda S., Das K. K. By Chemistry An European Journal - (2020)
Principal Investigator
- Total Synthesis of Spiroketal based Natural Products having Cytotoxicity against Caner Cell Lines and Development of Catalytic, Asymmetric Functionalization of Olefin
- Transition Metal Catalyzed C-C Bond Forming Reaction using Geminal bis (Pinacolboronate)
- Transition Metal Free Synthesis and Functionalization of Biaryls and Heterobiaryls through 1,2-Migration of Boronate Complex
Ph. D. Students
Debasis Aich
Area of Research: Organic chemistry
Debraj Ghorai
Area of Research: Organic chemistry
Kanak Kanti Das
Area of Research:
Pranjal Pyne
Area of Research: Organic chemistry
Saleha Khatun
Area of Research: Organic chemistry
Samir Manna
Area of Research: Organic chemistry
Somenath Mahato
Area of Research: Organic synthesis
Subrata Hazra
Area of Research: Organic synthesis
Suparna Mondal
Area of Research: Organic chemistry
Swagata Paul
Area of Research: Organic chemistry
